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KMID : 0379520000160010059
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한국독성학회지
2000 Volume.16 No. 1 p.59 ~ p.61
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A Single Nucleotide Polymorphism in Transforming Growth Factor-beta type II Receptor of the Rat
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Ryu Doug-Young
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Abstract
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A single nucleotide polymorphism in the transforming growth factor-beta type II receptor (TGEbetaRII) gene of the rat was studied. TGFbetaRII is a tumor suppressor that is frequently inactivated by mutation in human colon cancers. A novel nucleotide polymorphism of G to A(or A to G), which causes a silent mutation at codon 129, was found in G:C rich sequence in the TGFbetaRII gene of Sprague-Dawley rats. The results suggest that genetic polymorphism occures without a strain of the laboratory animal.
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KEYWORD
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Transforming growth factor-beta type II receptor, Nucleotide polymorphism
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